연구단계 | 1단계 : 2년차 | ||
논문제목(영문) | Comparison of the effects of two low-density lipoprotein cholesterol goals for secondary prevention after acute myocardial infarction in real-world practice: ≥ 50% reduction from baseline versus <70 mg/dL. | ||
국내외구분 | 국외 | SCI여부 | SCI |
연구책임자역활 | 교신저자 | 논문기여율 | 30% |
주저자명 | Cho KH | ||
교신저자명 | Jeong MH | ||
공동저자명 | Park KW, Kim HS, Lee SR, Chae JK, Hong YJ, Kim JH, Ahn Y, Cho JG, Park JC | ||
게제년월일 | 2015-03-26 | ||
ISSN | 0167-5273 | ||
Impact Factor | 6.175 | ||
학술지명 | Int J Cardiol | ||
서지사항 | 0집 / Epub권 / 0호, 페이지(0 - 0) | ||
병기표기 | 단독 | ||
Acknowledgement 기재여부 |
예
※ Acknowledgement가 기재된 논문만 연구과제의 성과로 인정. - 국문 표기 : "본 연구는 보건복지부 보건의료연구개발사업의 지원에 의하여 이루어진 것임. (HI13C1527)" - 영문 표기 : "This study was supported by a grant of the Korean Health Technology R&D Project, (HI13C1527) Ministry of Health & Welfare, Republic of Korea. " |
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요약초록문 (Abstract) 입력 |
Background The present study compared the effects of two low-density lipoprotein cholesterol (LDL-C) goals for secondary prevention after acute myocardial infarction (AMI) in real-world practice. Methods and Results Of 3,091 consecutive patients with AMI who had baseline LDL-C levels ≥70 mg/dL and underwent successful percutaneous coronary intervention, 1,305 eligible patients who received discharge statin prescriptions were analyzed. Patients were categorized into 2 groups according to the values of LDL-C at 1 year in two different manners using percent reduction from baseline (≥50% reduction, n=428 versus <50% reduction, n=877) and fixed levels (<70 mg/dL, n=625 versus ≥70 mg/dL, n=680). The primary outcome was defined by the composite of 2-year major cardiac events including cardiac death, non-fatal myocardial infarction, percutaneous coronary intervention, and coronary artery bypass grafting after hospital discharge. At 2 years, major cardiac events occurred in 139 patients (10.7%). Compared with <50% LDL-C reduction from baseline, patients with ≥50% LDL-C reduction had a 47% risk reduction in major cardiac events (adjusted hazard ratio, 0.53; 95% confidence interval, 0.36 to 0.79; P=0.002). But, compared with LDL-C levels ≥70 mg/dL at 1 year, patients with LDL-C levels <70 mg/dL at 1 year had a similar risk of major cardiac events (adjusted hazard ratio, 0.96; 95% confidence interval, 0.68 to 1.34; P=0.793). Conclusions Obtaining a ≥50% reduction in LDL-C was associated with better clinical outcomes after AMI in real-world practice, whereas achieving a <70 mg/dL was not. |
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