연구단계 | 1단계 : 2년차 | ||
논문제목(영문) | Reliable femoral chronic total occlusion model using a thin biodegradable polymer coated copper stent in a porcine model. | ||
국내외구분 | 국외 | SCI여부 | SCI |
연구책임자역활 | 교신저자 | 논문기여율 | 30% |
주저자명 | Kim NY, Lim KS | ||
교신저자명 | Jeong MH | ||
공동저자명 | Bae IH, Park JK, Nah JW, Park DS, Lee SY, Jang EJ, Kim JM, Kim JH, Kee HJ, Cho SN, Sim DS, Park KH, Hong YJ, Oh SG, Kim SH, Ahn Y, Kang JC. | ||
게제년월일 | 2015-04-01 | ||
ISSN | 0957-4530 | ||
Impact Factor | 2.379 | ||
학술지명 | J Mater Sci Mater Med | ||
서지사항 | 0집 / 26권 / 4호, 페이지(5506 - 5506) | ||
병기표기 | 단독 | ||
Acknowledgement 기재여부 |
예
※ Acknowledgement가 기재된 논문만 연구과제의 성과로 인정. - 국문 표기 : "본 연구는 보건복지부 보건의료연구개발사업의 지원에 의하여 이루어진 것임. (HI13C1527)" - 영문 표기 : "This study was supported by a grant of the Korean Health Technology R&D Project, (HI13C1527) Ministry of Health & Welfare, Republic of Korea. " |
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요약초록문 (Abstract) 입력 |
Chronic total occlusions (CTOs) are common in patients with peripheral arterial disease (PAD). This study aimed to examine the feasibility and reliability of a CTO induced by a thin biodegradable polymer (polyglycolic acid) coated copper stent in a porcine femoral artery. Novel thin biodegradable polymer coated copper stents (9 mm long) were crimped on an angioplasty balloon (4.5 mm diameter × 12 mm length) and inserted into the femoral artery. Histopathologic analysis was performed 35 days after stenting. In five of six stented femoral arteries, severe in-stent restenosis and total occlusion with collateral circulation were observed without adverse effects such as acute stent thrombosis, leg necrosis, or death at 5 weeks. Fibrous tissue deposition, small vascular channels, calcification, and inflammatory cells were observed in hematoxylin-eosin, Carstair's, and von Kossa tissue stains; these characteristics were similar to pathological findings associated with CTOs in humans. The neointima volume measured by micro-computed tomography was 93.9 ± 4.04 % in the stented femoral arteries. CTOs were reliably induced by novel thin biodegradable polymer coated copper stents in porcine femoral arteries. Successful induction of CTOs may provide a practical understanding of their formation and application of an interventional device for CTO treatment. |
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