연구단계 | 1단계 :1년차 | ||
논문제목(영문) | Fabrication of biomimetic PCL scaffold using rapid prototyping for bone tissue engineering. | ||
국내외구분 | 국외 | SCI여부 | SCI |
연구책임자역활 | 주저자 | 논문기여율 | 30% |
주저자명 | SA Park | ||
교신저자명 | SA Park | ||
공동저자명 | Lee JB, Kim YE, Kim JE, Lee JH, Shin JW, Kwon IK, Kim WD | ||
게제년월일 | 2014-08-31 | ||
ISSN | 1598-5032 | ||
Impact Factor | 1.682 | ||
학술지명 | Macromol Res | ||
서지사항 | 0집 / 22권 / 8호, 페이지(882 - 887) | ||
병기표기 | 단독 | ||
Acknowledgement 기재여부 |
예
※ Acknowledgement가 기재된 논문만 연구과제의 성과로 인정. - 국문 표기 : "본 연구는 보건복지부 보건의료연구개발사업의 지원에 의하여 이루어진 것임. (HI13C1527)" - 영문 표기 : "This study was supported by a grant of the Korean Health Technology R&D Project, (HI13C1527) Ministry of Health & Welfare, Republic of Korea. " |
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요약초록문 (Abstract) 입력 |
We report the fabrication of a porous three-dimensional (3D) scaffold using a 3D plotting system, with applications in bone tissue engineering. Biomimetic surface coatings of hydroxyapatite were formed using concentrated simulated body fluid (SBF). The mineralized scaffold had a uniform interconnected porous structure. The apatite that was formed on the surface of the scaffold was characterized by using energy dispersive spectroscopy (EDS), X-ray powder diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR). The biological properties of the scaffold were evaluated using WST-1 assays of alkaline phosphatase (ALP) activity and gene expression of D1 mouse mesenchymal stem cells. The results show that the biomimetic scaffolds exhibited good apatite-forming properties, with favorable cell proliferation and differentiation for bone formation. Therefore, these biomimetic scaffolds with hydroxyapatite coatings have potential applications in bone regeneration. |
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