작성일 : 14-09-21 15:13
| 연구단계 | 1단계 :1년차 | ||
| 논문제목(영문) | A one year longitudinal study of cytokine genes and depression in breast cancer. | ||
| 국내외구분 | 국외 | SCI여부 | SCI |
| 연구책임자역활 | 주저자 | 논문기여율 | 30% |
| 주저자명 | Kim JM | ||
| 교신저자명 | Yoon JS | ||
| 공동저자명 | Stewart R, Kim SY, Kang HJ, Jang JE, Kim SW, Shin IS, Park MH, Yoon JH, Park SW, Kim YH | ||
| 게제년월일 | 2013-05-15 | ||
| ISSN | 0165-0327 | ||
| Impact Factor | 3.705 | ||
| 학술지명 | J Affect Disord | ||
| 서지사항 | 0집 / 148권 / 1호, 페이지(57 - 65) | ||
| 병기표기 | 단독 | ||
| Acknowledgement 기재여부 |
예
※ Acknowledgement가 기재된 논문만 연구과제의 성과로 인정. - 국문 표기 : "본 연구는 보건복지부 보건의료연구개발사업의 지원에 의하여 이루어진 것임. (HI13C1527)" - 영문 표기 : "This study was supported by a grant of the Korean Health Technology R&D Project, (HI13C1527) Ministry of Health & Welfare, Republic of Korea. " |
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| 요약초록문 (Abstract) 입력 |
BACKGROUND: Since inflammatory cytokines have been implicated in the pathophysiology of both cancer and depression, genes that contribute to determining cytokine functional activity are reasonable candidate risk factors for depression related to cancer. This study aimed to investigate whether alleles related to higher pro-inflammatory and/or lower anti-inflammatory cytokine production would associate with depression in a cohort with breast cancer. METHODS: A total of 309 women with breast cancer were evaluated one week after surgery, and 244 (79%) were followed one year later. Depression (major+minor depressive disorders) was diagnosed according to DSM-IV criteria using the Mini International Neuropsychiatric Interview on both occasions. Six pro-(TNF-α-850C/T and -308G/A, IL-1β-511C/T and +3953C/T, IL-6-174G/C, IL-8-251T/A) and two anti-inflammatory (IL-4 +33T/C, IL-10-1082G/A) cytokine polymorphisms were assayed, and total numbers of potential risk alleles were calculated for pro- and anti-inflammatory cytokine genes. Adjustments were made for demographic and clinical characteristics. RESULTS: At baseline, 74 (24%) patients were classified with prevalent depression; and at follow-up, 19 (8%) and 25 (10%) patients were classified with persistent and incident depression, respectively. A higher number of pro-inflammatory cytokine risk alleles, and IL-1β-511T/T genotype individually, were independently associated with both prevalent depression at baseline and persistent depression at one year follow-up. LIMITATIONS: Sample size was relatively small. CONCLUSIONS: Our findings support the role of pro-inflammatory cytokines in the etiology of depression related to breast cancer, and provide novel evidence of a potential genetic basis for this. |
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