작성일 : 14-09-21 15:03
| 연구단계 | 1단계 :1년차 | ||
| 논문제목(영문) | Proximal arterial occlusion in acute ischemic stroke with low NIHSS scores should not be considered as mild stroke. | ||
| 국내외구분 | 국외 | SCI여부 | SCI |
| 연구책임자역활 | 주저자 | 논문기여율 | 30% |
| 주저자명 | Kim JT | ||
| 교신저자명 | Park MS | ||
| 공동저자명 | Chang J, Lee JS, Choi KH, Cho KH | ||
| 게제년월일 | 2013-08-16 | ||
| ISSN | 1932-6203 | ||
| Impact Factor | 3.534 | ||
| 학술지명 | PLoS One | ||
| 서지사항 | 0집 / 8권 / 8호, 페이지(e70996 - e70996) | ||
| 병기표기 | 단독 | ||
| Acknowledgement 기재여부 |
예
※ Acknowledgement가 기재된 논문만 연구과제의 성과로 인정. - 국문 표기 : "본 연구는 보건복지부 보건의료연구개발사업의 지원에 의하여 이루어진 것임. (HI13C1527)" - 영문 표기 : "This study was supported by a grant of the Korean Health Technology R&D Project, (HI13C1527) Ministry of Health & Welfare, Republic of Korea. " |
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| 요약초록문 (Abstract) 입력 |
BACKGROUND: Untreated acute mild stroke patients have substantial 90-day disability rates and worse outcomes than those who are treated with thrombolysis. There is little information regarding which patients with acute mild stroke will benefit from thrombolysis. We sought to investigate factors that are associated with early neurological deterioration (END) and poor prognosis in patients with acute mild stroke. METHODS: This was a retrospective study of consecutively registered patients with acute mild stroke (NIHSS ≤3) at our tertiary stroke center between October 2008 and December 2011. END was defined as an increase in NIHSS ≥2 points between hospital days 0 and 5. Modified Rankin Scale (mRS) scores of 0-1 at 90 days post-stroke were defined as favorable outcomes. RESULTS: A total of 378 (mean age, 65.9±13.0 years) patients were included in this study. END occurred in 55 patients (14.6%). IV-thrombolysis was performed in only 9 patients. Symptomatic arterial occlusion on the initial MRA was independently associated with END (OR, 2.206; 95% CI, 1.219-3.994; p = 0.009) by multivariate logistic regression. Of the 119 patients with symptomatic arterial occlusion, ICA occlusion was independently associated with END (OR, 8.606; 95% CI, 2.312-32.043; p = 0.001). CONCLUSIONS: This study demonstrates that symptomatic arterial occlusion may be an important predictor of END in patients with acute mild stroke. It may therefore be important to consider that acute ischemic stroke with symptomatic arterial occlusion and low NIHSS scores may not represent mild stroke in acute periods. |
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